[Research update on pharmacogenomics in acute leukemia - review]
Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2008 Jun;16(3):704-11
Authors: Li L, Xiao ZJ
Pharmacogenomics, a new subject aiming to elucidate genetic basis for inter individual differences in response on a drug and to predict the safety and efficacy of drugs by the genetic information, which guides to clinical individual therapy, breaks a new way to apply drugs rationally to acute leukemia. This article reviewed the enzymes related to metabolism, transport and acting point of the drugs used in the treatment of acute leukemia and discussed the influence of their coding gene's polymorphism on drug adverse effects and disease prognosis.
PMID: 18549659 [PubMed - indexed for MEDLINE]