Adaptive Pharmacogenomics, LLC

Clinical development for personalized medicine

Sunday, August 1, 2010 | 4:41 AM

Archive

Tacrolimus nephrotoxicity: beware of the association of diarrhea, drug interaction and pharmacogenetics.

Pediatr Nephrol. 2010 May;25(5):965-9

Authors: Leroy S, Isapof A, Fargue S, Fakhoury M, Bensman A, Deschênes G, Jacqz-Aigrain E, Ulinski T

Tacrolimus is known to potentially lead to adverse events in recipients with diarrhoea and/or calcium channel blocker (CCB) co-administration.

Jun 20, 2010 03:23 AM

[60 years of medical genetics in Israel]

[60 years of medical genetics in Israel]

Harefuah. 2010 Feb;149(2):91-4, 124

Authors: Shalev SA, Borochowitz ZU, Zlotogora J

The principle deeds of genetics in Israel consist of a wide array of disciplines including agriculture, nutrients, biotechnology, pharmacology and pharmacogenetics, pertaining to criminal as well as medical aspects.

Jun 18, 2010 03:23 AM

Q&A: Mark Levin

MassBio asked Mark Levin, a partner at Third Rock Ventures for his thoughts on the economic climate, the future of venture capital and hot new science. Here's what he had to say.

Q: It has been said that Third Rock looks for “Big Science” to invest in. As you look to the next 10 years out, what do you see now that has the capability to qualify as "big science?"

A: Well I guess a couple things. Certainly that’s true; we do look for big science. We also try to balance the portfolio.

Jun 17, 2010 12:00 PM

Decision criteria for rational selection of homogeneous genotyping platforms for pharmacogenomics testing in clinical diagnostics.

Clin Chem Lab Med. 2010 Apr;48(4):447-59

Authors: Di Francia R, Frigeri F, Berretta M, Cecchin E, Orlando C, Pinto A, Pinzani P

BACKGROUND: Genotyping is crucial for the identification of genetic markers underlying the development of neoplastic diseases and for determining individual variations in response to specific drugs.

Jun 17, 2010 03:23 AM

Bioethics and the reinforcement of socio-technical expectations.

Soc Stud Sci. 2010 Apr;40(2):163-86

Authors: Hedgecoe A

Over the past few years, considerable interest has been paid to the way in which social expectations (hopes, hypes, fears) about new genomic technologies help shape, and in themselves are shaped by, emerging technologies, regulatory regimes and social concerns.

Jun 16, 2010 03:23 AM

Pharmacogenetics of adverse effects due to antiretroviral drugs.

AIDS Rev. 2010 Jan-Mar;12(1):15-30

Authors: Vidal F, Gutiérrez F, Gutiérrez M, Olona M, Sánchez V, Mateo G, Peraire J, Viladés C, Veloso S, López-Dupla M, Domingo P

The availability of highly active antiretroviral therapy has markedly improved the survival rate and quality of life in patients infected with HIV.

Jun 16, 2010 03:23 AM

Naltrexone for the treatment of alcoholism: clinical findings, mechanisms of action, and pharmacogenetics.

CNS Neurol Disord Drug Targets. 2010 Mar;9(1):13-22

Authors: Ray LA, Chin PF, Miotto K

Naltrexone is an opioid receptor antagonist with established efficacy, albeit moderate, for the treatment of alcohol dependence.

Jun 16, 2010 03:23 AM

New biomarker for raw milk quality detection

New findings at Nanjing University lead to a completely new standard for milk quality control, and possible new milk products with specific usage in the future.
Jun 15, 2010 12:00 AM

Biomarker finding could help treat patients with aggressive type of lung cancer

Researchers have discovered a biomarker that could help in the treatment of patients with an aggressive type of lung cancer. Using a particular biomarker, researchers might better predict which patients with small cell lung cancer are resistant to existing drug therapies, and which ones could benefit from new therapies tailored to their specific needs.
Jun 14, 2010 11:00 PM
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