Archive
Tacrolimus nephrotoxicity: beware of the association of diarrhea, drug interaction and pharmacogenetics.
Pediatr Nephrol. 2010 May;25(5):965-9
Authors: Leroy S, Isapof A, Fargue S, Fakhoury M, Bensman A, Deschênes G, Jacqz-Aigrain E, Ulinski T
Tacrolimus is known to potentially lead to adverse events in recipients with diarrhoea and/or calcium channel blocker (CCB) co-administration.
ADME pharmacogenetics: investigation of the pharmacokinetics of the antiretroviral agent lopinavir coformulated with ritonavir.
Pharmacogenet Genomics.
[60 years of medical genetics in Israel]
[60 years of medical genetics in Israel]
Harefuah. 2010 Feb;149(2):91-4, 124
Authors: Shalev SA, Borochowitz ZU, Zlotogora J
The principle deeds of genetics in Israel consist of a wide array of disciplines including agriculture, nutrients, biotechnology, pharmacology and pharmacogenetics, pertaining to criminal as well as medical aspects.
Q&A: Mark Levin
MassBio asked Mark Levin, a partner at Third Rock Ventures for his thoughts on the economic climate, the future of venture capital and hot new science. Here's what he had to say.
Q: It has been said that Third Rock looks for “Big Science” to invest in. As you look to the next 10 years out, what do you see now that has the capability to qualify as "big science?"
A: Well I guess a couple things. Certainly that’s true; we do look for big science. We also try to balance the portfolio.
Decision criteria for rational selection of homogeneous genotyping platforms for pharmacogenomics testing in clinical diagnostics.
Clin Chem Lab Med. 2010 Apr;48(4):447-59
Authors: Di Francia R, Frigeri F, Berretta M, Cecchin E, Orlando C, Pinto A, Pinzani P
BACKGROUND: Genotyping is crucial for the identification of genetic markers underlying the development of neoplastic diseases and for determining individual variations in response to specific drugs.
Bioethics and the reinforcement of socio-technical expectations.
Soc Stud Sci. 2010 Apr;40(2):163-86
Authors: Hedgecoe A
Over the past few years, considerable interest has been paid to the way in which social expectations (hopes, hypes, fears) about new genomic technologies help shape, and in themselves are shaped by, emerging technologies, regulatory regimes and social concerns.
Pharmacogenetics of adverse effects due to antiretroviral drugs.
AIDS Rev. 2010 Jan-Mar;12(1):15-30
Authors: Vidal F, Gutiérrez F, Gutiérrez M, Olona M, Sánchez V, Mateo G, Peraire J, Viladés C, Veloso S, López-Dupla M, Domingo P
The availability of highly active antiretroviral therapy has markedly improved the survival rate and quality of life in patients infected with HIV.
Naltrexone for the treatment of alcoholism: clinical findings, mechanisms of action, and pharmacogenetics.
CNS Neurol Disord Drug Targets. 2010 Mar;9(1):13-22
Authors: Ray LA, Chin PF, Miotto K
Naltrexone is an opioid receptor antagonist with established efficacy, albeit moderate, for the treatment of alcohol dependence.