Adaptive Pharmacogenomics, LLC

Curr Drug Metab. 2009 Nov;10(9):956-70

Authors: Andrade RJ, Agúndez JA, Lucena MI, Martínez C, Cueto R, García-Martín E

Drug-induced liver injury (DILI) is a severe adverse effect. The majority of DILI cases are idiosyncratic and several mechanisms have been postulated to explain why some subjects develop DILI with drugs that are safe for the majority of individuals.

 

The BioPharm America 2010/MassBio Investors Forum will be held on September 15-17 at the Copley Marriott in Boston, MA.

In partnership with BioPharm America, the MassBio Investors Forum will bring together companies from across the globe to partner and invest in Massachusetts most innovative companies.

MassBio and EBD Group will make this combined North America’s premiere partnering events -- creating a unique, high powered business exchange that unites the international life sciences community.

Genet Test Mol Biomarkers. 2010 Feb;14(1):121-5

Authors: Higgs J, Gambhir N, Ramsden SC, Poulton K, Newman WG

AIM: For certain drugs, pharmacogenetic tests can reduce adverse drug reactions and improve treatment efficacy. However, the adoption of pharmacogenetics into clinical practice has been relatively slow.

Blood.

Nephrologists must consider fluid overload effects when prescribing dialysis, according to a new study. The fluid overload biomarker, N-terminal pro-brain-type natriuretic peptide (NT-pro-BNP), previously known as a "cardiac biomarker" in dialysis patients, is an important component of managing patients with kidney disease.

Eur Heart J. 2009 Aug;30(16):1964-77

Authors: Wallentin L

Currently, clopidogrel is recommended for treatment of patients with acute coronary syndrome and/or percutaneous coronary intervention.

Doxorubicin-induced suppression of poly(ADP-ribose) polymerase-1 (PARP-1) activity and expression and its implication for PARP inhibitors in clinical trials.

Cancer Chemother Pharmacol. 2010 May 21;

Authors: Zaremba T, Thomas H, Cole M, Plummer ER, Curtin NJ

PURPOSE: Monozygotic twins provide an excellent tool to study environmental effects on human health.

Psychiatr Clin North Am. 2010 Mar;33(1):181-224

Authors: Zandi PP, Judy JT

Existing psychotropic medications for the treatment of mental illnesses, including antidepressants, mood stabilizers, and antipsychotics, are clinically suboptimal. They are effective in only a subset of patients or produce partial responses, and they are often associated with debilitating side effects that discourage adherence.

Genome-wide pharmacogenetics of antidepressant response in the GENDEP project.

Am J Psychiatry.