Archive
Bioinformatics for transporter pharmacogenomics and systems biology: data integration and modeling with UML.
Methods Mol Biol. 2010;637:23-45
Authors: Yan Q
Bioinformatics is the rational study at an abstract level that can influence the way we understand biomedical facts and the way we apply the biomedical knowledge.
Genetic predisposition to adverse drug reactions in the intensive care unit.
Crit Care Med. 2010 Jun;38(6 Suppl):S106-16
Authors: Empey PE
Adverse drug reactions are a significant public health problem that leads to mortality, hospital admissions, an increased length of stay, increasing healthcare costs, and withdrawal of drugs from market. Intensive care unit patients are particularly vulnerable and are at an elevated risk.
Membrane transporters and drug development: relevance to pharmacogenomics, nutrigenomics, epigenetics, and systems biology.
Methods Mol Biol. 2010;637:1-21
Authors: Yan Q
The study of membrane transporters may result in breakthroughs in the discovery of new drugs and the development of safer drugs. Membrane transporters are essential for fundamental cellular functions and normal physiological processes. These molecules influence drug absorption and distribution and play key roles in drug therapeutic effects.
Personalized immunosuppressive therapy in pediatric heart transplantation: Progress, pitfalls and promises.
Pharmacol Ther. 2010 May;126(2):146-58
Authors: Xie HG
The use of the immunosuppressants has revolutionized organ transplantation, including pediatric heart transplantation (PHTx).
Study finds brain imaging and biomarker assessments helpful in early identification of Alzheimer’s disease
Efflux and uptake transporters as determinants of statin response.
Expert Opin Drug Metab Toxicol. 2010 May;6(5):621-32
Authors: Rodrigues AC
IMPORTANCE OF THE FIELD: The important role of drug transporters in drug absorption and disposition has been well documented.
Genetic variation in the natriuretic peptide system and heart failure.
Heart Fail Rev. 2010 May;15(3):219-28
Authors: Lanfear DE
Heart failure (HF) is a modern epidemic and is one of the few cardiovascular diseases which is increasing in prevalence. The growing importance of the Natriuretic Peptide (NP) system in HF is well recognized.
Beta-blocker pharmacogenetics in heart failure.
Heart Fail Rev. 2010 May;15(3):187-96
Authors: Shin J, Johnson JA
Beta-blockers (metoprolol, bisoprolol, and carvedilol) are a cornerstone of heart failure (HF) treatment. However, it is well recognized that responses to a beta-blocker are variable among patients with HF.
Renin-angiotensin-aldosterone system (RAAS) pharmacogenomics: implications in heart failure management.
Heart Fail Rev. 2010 May;15(3):209-17
Authors: Beitelshees AL, Zineh I
Blockade of the renin-angiotensin-aldosterone system (RAAS) with ACE inhibitors has been a cornerstone of heart failure therapy for over 15 years. More recently, further blockade of RAAS with aldosterone antagonists and angiotensin receptor blockers (ARBs) has been studied.
Pharmacogenetics of drug-induced liver injury.
Pharmacogenetics of drug-induced liver injury.
Hepatology. 2010 Apr 19;
Authors: Russmann S, Jetter A, Kullak-Ublick GA
Recent progress in research on drug-induced liver injury (DILI) has been determined by key developments in two areas. First, new technologies allow the identification of genetic risk factors with improved sensitivity, specificity, and efficiency.