Adaptive Pharmacogenomics, LLC

High energy levels cause glioblastoma cells to proliferate; low levels cause them to grow less and to migrate. This study discovered that a molecule called miR-451 coordinates this grow-or-go behavior, which is closely linked to the cells' ability to invade and spread. Thus, the molecule might be a biomarker for predicting survival in patients with glioblastoma multiforme and may serve as a target to develop drugs to fight these tumors.

Heart Fail Clin. 2010 Jan;6(1):25-6

Authors: Pauly DF

Analyses of polymorphisms in the renin-angiotensin system may never completely predict responsiveness to pharmacotherapy that blocks angiotensin-converting enzyme or the angiotensin receptor type 1.

Pharmacogenetics of antipsychotic-induced side effects.

Dialogues Clin Neurosci. 2009;11(4):405-15

Authors: Lencz T, Malhotra AK

Currently available antipsychotic drugs (APDs) carry significant though highly variable, liability to neurologic and metabolic side effects. Pharmacogenetics approaches offer the possibility of identifying patient-specific biomarkers for predicting risk of these side effects.

Heart Fail Clin. 2010 Jan;6(1):1-10

Authors: Hamad E, Feldman AM

Pharmacogenomics is a growing field of research that focuses on how an individual's genetic background influences his or her response to therapy with a drug or device.

The intersection of pharmacology, imaging, and genetics in the development of personalized medicine.

Dialogues Clin Neurosci. 2009;11(4):363-76

Authors: Gerretsen P, Müller DJ, Tiwari A, Mamo D, Pollock BG

We currently rely on large randomized controlled trials and meta-analyses to make clinical decisions; this places us at a risk of discarding subgroup or individually specific treatment options owing to their failure to prove efficacious across entire populations.

DMET Microarray Technology for Pharmacogenomics-Based Personalized Medicine.

Methods Mol Biol.

Int J Clin Pharmacol Ther. 2010 Jan;48(1):1-10

Authors: Kuhn UD, Anschütz M, Schmücker K, Schug BS, Hippius M, Blume HH

OBJECTIVE: N-acetyltransferase 2 (NAT2) genotype-phenotype relation with sulfasalazine as probe drug by means of detailed genotype analysis and kinetic data evaluation.

High energy levels cause glioblastoma cells to proliferate; low levels cause them to grow less and to migrate. This study discovered that a molecule called miR-451 coordinates this grow-or-go behavior, which is closely linked to the cells' ability to invade and spread. Thus, the molecule might be a biomarker for predicting survival in patients with glioblastoma multiforme and may serve as a target to develop drugs to fight these tumors.

"Understanding Cancer through Human Tissue-based Models,"

the Human Tissue Research Conference (HTRC) 2010

sponsored by Asterand

 

This inaugural 2 day conference will be held April 14-15, 2010. in Washington D. C. (directly preceding the 101st AACR Annual Meeting).

The conference will provide an intimate forum for researchers and key industry leaders to share insight and experience with one another on the use of human tissue in basic research, diagnostics, biotechnology and the pharmaceutical industry.

Species differences in pharmacokinetics and pharmacodynamics.

Handb Exp Pharmacol. 2010;199:19-48

Authors: Toutain PL, Ferran A, Bousquet-Mélou A

Veterinary medicine faces the unique challenge of having to treat many types of domestic animal species, including mammals, birds, and fishes.